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On
September 19, 2013, an article was published online in JAMA Ophthalmology that
verified the association between statin use and development of cataracts.
Researchers from Texas and Alexandria, Egypt
collaborated on the study to determine the impact of statins on successive
health of the eye.
Statins are medications that belong to the
HMG-CoA reductase inhibitor class of drugs. These medications are indicated for
lowering elevated levels of cholesterol, and are to be used in
conjunction with proper diet and exercise.
There have been conflicting findings regarding the
relationship between statins and resulting cataract disease (clouding of the
lens within the eye), and investigators sought to clarify the link in question.
Researchers aggregated records from a military
health care system database, and created matched patient cohorts of statin
users vs. nonusers based on 44 different variables.
The final analysis included records of 6,972
matched patients (13,944 total), and adjusted for potential confounding
factors. Investigators found that patients treated with statins had a 27%
increased chance of developing cataract disease compared to patients who had
not taken such medications.
Statins (Advicor, Caduet, Crestor, Juvisync,
Lescol, Lipitor, Livalo, Mevacor, Pravachol, Simcor, Vytorin, Zocor) are
medications that belong to the HMG-CoA reductase inhibitor class of drugs.
These drugs are indicated for lowering elevated
levels of cholesterol in combination with diet and exercise. Mevacor
(lovastatin) was approved on August 31, 1987 by the FDA, and other statins were
subsequently approved.
Using FAERS data (from 11/01/1997 to 12/31/2012),
aggregated and standardized by the AdverseEvent RxFilter process, the team
identified 692 reports of cataract conditions where statins were listed as the
primary suspect drug. Of these cases, the team identified 113 hospitalizations
and 64 cases of disability.
Note: In order to calculate the total number of
cases involving cataract conditions, we aggregated reports listing the
following adverse events: MedDRA Preferred Term: Cataract operation; MedDRA
High-Level Term: Cataract conditions.
http://bit.ly/19NG2vr
سیزدهمین همایش کشوری دانش و تندرستی
تاریخ برگذاری همایش: 27/9/1392 الی 28/9/1392
لینک ارسال مقالات http://hamayesh.shmu.ac.ir
آخرین مهلت ارسال مقالات 30/7/1392